Endocrine Abstracts

Background: Vitamin D (25(OH)D) deficiency is a global public health issue. An association with obesity and diabetes has been described in adult and paediatric populations. This study investigates the prevalence of 25(OH)D deficiency and its correlates in population of Emirati children and adolescents attending a large diabetes centre in the United Arab Emirates.Methods: Participants aged 4-19 years were selected based on diabetes status [type 1 diabetes...

Background: Non-functioning pituitary tumours can be associated with a modestly elevated prolactin. Response to dopamine agonist therapy in such cases is unusual. Large macroprolactinomas are associated with much higher prolactin levels and respond well to dopamine agonists.Case: We report a 41-year-old man with a pituitary macroadenoma associated with an elevated prolactin of around 2000mIU/l who developed marked resolution in his pituitary MRI images r...

Introduction: Liver transaminases are markers of parenchymal liver disease, most commonly non-alcoholic steatohepatitis (NASH), the inflammatory component of non-alcoholic fatty liver disease (NAFLD). Common causes include obesity and type 2 diabetes mellitus (T2DM), both common conditions in the UAE. The prevalence of NAFLD in this population is not known. We report data from a large diabetes centre including ALT and aspartate transaminase (AST) levels in patients with and wi...

Background: Obesity is increasing in prevalence in younger people, including children and adolescents. Bariatric surgery (BS) is well-established and efficacious treatment for morbid obesity in adults. BS is being performed in younger age groups more frequently.Objective: To describe outcomes of BS under the age of 25 in Emirati individuals having follow-up at Imperial College London Diabetes Centre (ICLDC).Methods: Patients recrui...

Background: Cardiovascular disease (CVD) is a leading cause of mortality. Childhood obesity is a major contributor to CVD. Atherogenic index of plasma (AIP) is an indicator of risk of atherosclerotic CVD. Associations between childhood obesity and CVD risk in the region remains under-explored. We aim to investigate this association as a predictor of CVD in this young population.Methods: Patients who attended our Centre (2009-2019), age ≤19 years an...

Background: The obesity prevalence surge in children and adolescents is associated with dysglycaemia, dyslipidaemia and long-term cardiovascular complications. Use of lipid-lowering medications1 has been recommended following lifestyle modifications. We aim to investigate the demographic, and changes in LDL-c, in these young patients, in the presence and absence of dysglycaemia.Methods: Complete lipid profiles of patients (≤19 years old)...

Background: Obesity is highly prevalent in the Middle East. Treatment is a challenge and with an aging population, therapy in the elderly poses new problems. Published data on efficacy of bariatric surgery in the older age groups are scant.Aims: The objective of this study was to assess the outcomes of bariatric surgery (BS) in the elderly (≥65 years) in the UAE population.Methods: ICLDC patient database was accessed to ident...

Background and aims: We previously reported BMI heritability in the UAE to be 39.9%; indicating a high (60.1%) contribution of environmental factors to obesity. This study aims to determine and compare co-twin monozygotic (MZ) and dizygotic (DZ) BMI concordances.Materials and methods: 200 twin pairs were identified (ICLDC patient database) and split into two age groups (≤18 and >18 years old). Opposite gender twin sets were considered DZ. In same g...

Background: Interest is rising in the use of traditional food as potential treatments for diabetes. In some arid regions camel milk is believed to have special health promoting properties. Some studies have linked consumption of camel milk to diabetes prevention in addition to describing hypoglycaemic effects in those with diabetes. The potential mechanism is incompletely understood.Aims: To investigate the impact on glucose metabolism after a mixed meal...

Background: Down Syndrome (DS) is the most common chromosomal abnormality. Obesity and type 1 diabetes mellitus (T1DM) are known to be more prevalent in patients with DS than the general population. Available data on the prevalence of type 2 diabetes mellitus (T2DM) in DS is scant.Objectives: This study aims to investigate the prevalence of obesity and diabetes mellitus (DM) in adults with DS seen in Imperial College London Diabetes Centre (ICLDC) in the...